Numerical Inversion Methods for Computing Approximate p-Values

Approximate P-Values for Local Sequence Alignments: Numerical Studies

Siegmund and Yakir (2000) have given an approximate p-value when two independent, identically distributed sequences from a finite alphabet are optimally aligned based on a scoring system that rewards similarities according to a general scoring matrix and penalizes gaps (insertions and deletions). The approximation involves an infinite sequence of difficult-to-compute parameters. In this paper, ...

Numerical Methods for Laplace Transform Inversion

Computing exact P-values for DNA motifs

MOTIVATION Many heuristic algorithms have been designed to approximate P-values of DNA motifs described by position weight matrices, for evaluating their statistical significance. They often significantly deviate from the true P-value by orders of magnitude. Exact P-value computation is needed for ranking the motifs. Furthermore, surprisingly, the complexity of the problem is unknown. RESULTS...

Distributed Methods for Computing Approximate Equilibria

We present a new, distributed method to compute approximate Nash equilibria in bimatrix games. In contrast to previous approaches that analyze the two payoff matrices at the same time (for example, by solving a single LP that combines the two players payoffs), our algorithm first solves two independent LPs, each of which is derived from one of the two payoff matrices, and then compute approxima...

Imprecise Minority-Based Full Adder for ‎Approximate Computing Using CNFETs

   Nowadays, the portable multimedia electronic devices, which employ signal-processing modules, require power aware structures more than ever. For the applications associating with human senses, approximate arithmetic circuits can be considered to improve performance and power efficiency. On the other hand, scaling has led to some limitations in performance of nanoscale circuits. According...